If you take too much colchicine capsules, call your healthcare provider or go to the nearest hospital emergency room right away. Keep a list of your medicines with you to show your healthcare provider and pharmacist each time you get a new medicine. Using colchicine capsules with certain other medicines can affect each other causing serious side effects and/or death. Colchicine can pass into your breast milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take colchicine capsules. It is not known if colchicine capsules can harm your unborn baby.
Absolute bioavailability is reported to be approximately 45%. Colchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Colchicine is a substrate of the efflux transporter P-glycoprotein (P-gp), and the CYP3A4 metabolizing enzyme. Fatal drug interactions have been reported when colchicine is administered with clarithromycin, a dual inhibitor of CYP3A4 and P-glycoprotein. Colchicine capsules are indicated for prophylaxis of gout flares in adults.
Due to the potential for colchicine to produce aneuploid cells , colchicine presents a theoretical increased risk of malignancy. Myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, and aplastic anemia have been reported with colchicine used in therapeutic doses. Colchicine capsules are not an analgesic medication and should not be used to treat pain from other causes. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
If you have gout, you’ll probably experience painful swelling in your joints, particularly in your feet. You might have intermittent gout attacks, or flare-ups, which involve a sudden onset of pain and swelling. Gout can also lead to the development of inflammatory arthritis. For me a flare up in my feet feels like my foot is in a fire and your smashing it with a sledge hammer it’s very painful I cannot walk. Because colchicine is a substrate for both the CYP3A4 metabolizing enzyme and the P-glycoprotein efflux transporter, inhibition of either of these pathways may lead to colchicine-related toxicity. Therefore, concomitant use of colchicine capsules and inhibitors of CYP3A4 or Pglycoprotein should be avoided .
If avoidance is not possible, reduced daily dose should be considered and the patient should be monitored closely for colchicine toxicity. Use of colchicine capsules in conjunction with drugs that inhibit both P-gp and CYP3A4 is contraindicated in patients with renal or hepatic impairment . The ACR guidelines for acute gout flares include use of non-steroidal anti-inflammatory drugs , oral colchicine, and corticosteroids to achieve this goal.
Keeping your body at a healthy weight reduces your risk of gout. Choose low-impact activities such as walking, bicycling and swimming — which are easier on your joints. Drugs such as allopurinol and febuxostat help limit the amount of uric acid your body makes. Side effects of allopurinol include fever, rash, hepatitis and kidney problems.
Even medicines that you take for a short period of time, such as antibiotics, can interact with colchicine capsules and cause serious side effects or death. Gout is rare in pediatric patients; the safety and effectiveness of colchicine capsules in pediatric patients has not been evaluated in controlled studies. Limited information suggests that infants exclusively breastfed receive less than 10 percent of the maternal weight-adjusted dose. While there are no published reports of adverse effects in breast-feeding infants of mothers taking colchicine, colchicine can affect gastrointestinal cell renewal and permeability. Caution should be exercised and breastfeeding infants should be observed for adverse effects when colchicine capsules is administered to a nursing woman.
The sooner you start treatment and pain management, the more quickly you will be back on your feet. Lowers uric acid levels in blood, and prevents gout flare-ups. You can get kidney stones if your uric acid levels are very high, so you’ll need treatment to reduce the levels. As a gout sufferer along with my brother and son, we have not had attacks as long as we take a quality tart cherry supplement. Tart cherry juice works well too but the supplements don’t add more sugar to the diet. John, I never had a high serum level of uric acid until age thirty-seven after the FDA approved the expanded use of added MSG in 1980.
NSAIDs carry risks of stomach pain, bleeding and ulcers. You can help prevent a future gout flare-up noxzema sunburn by avoiding food and drinks high in purines. Talk with your doctor about the best medicines for you.